Björn Gylemo

About Me

I’m currently pursuing a PhD in Colm Nestors group at Linköping University, Linköping, Sweden.

I received my B.S. in medical laboratory science and my MSc in medical biology at Linköping University, Sweden. My research focuses on exploring how the inactive X-chromosome is regulated during human T cell development through integrative analyses of multimodality data, including single-cell and bulk allele-specific expression, DNA methylation and sex-biased gene expression. Furthemrore, I have studied variability of escape from X-chromosome inactivation (XCI) across tissue within the same individual. My current work mainly concern skewed XCI and its origin.

Research Interests

• X-chromosome inactivation
• Single cell technologies

News

• [Jan. 2025] Our paper about escape from XCI across multiple tissues within the same individuals is published in eLife!
• [Dec. 2024] Our paper investigating X-inactivation in human T cell development is published in Nature Communications!

Key Publications

First author papers

X-chromosome inactivation papers, first in T cell development and then across tissues within the same individual.

Other papers

Papers I’m on but not as first author. One paper on spermatogenesis and the Y-chromosome genes in mice, one paper on DNA N6-methyladenine in mammals.