Björn Gylemo
About Me
I’m currently pursuing a PhD in Colm Nestor’s group at Linköping University, Linköping, Sweden. I am defending my thesis on the 26th of Septemeber 2025.
I received my B.S. in medical laboratory science and my MSc in medical biology at Linköping University, Sweden. My research focuses on the inactive X-chromosome (Xi), where I’ve looked at how the Xi is regulated during human T cell development via integrative data analysis of single-cell, bulk allele-specific expression, DNA methylation and sex-biased gene expression. I have also studied variability of escape from X-chromosome inactivation across tissue within the same individual. My current work mainly concern skewed XCI and its origin where I primarily work with long read sequencing (nanopore) and scRNA-seq (smart-seq2). I am very interested in broadening my skills in data analysis/bioinfo but also within the field of biology. Outside of my main research area I have a very general interest in genetics, especially anything related to the sex chromosomes. Feel free to contact me if you have any questions.
Research Interests
- X-chromosome inactivation
- Single-cell technologies
- Long-read sequencing
News
- [Jan. 2025] Our paper about escape from XCI across multiple tissues within the same individuals is published in eLife!
- [Dec. 2024] Our paper investigating X-inactivation in human T cell development is published in Nature Communications!
Key Publications
First author papers
X-chromosome inactivation papers, first in T cell development and then across tissues within the same individual.
Other papers
Papers I’m on but not as first author. One paper on spermatogenesis and the Y-chromosome genes in mice, one paper on DNA N6-methyladenine in mammals.